Professor Mansoor Nasir
Department of Biomedical Engineering, Lawrence Technological University, Southfield, MI
Impedance measurements have been used for decades to size cells using instruments such as the Coulter Counters. The main drawback to such instruments is that channel through which the target particles pass must be roughly the same size as the particles themselves. Consequently, such devices clog frequently or require sophisticated sample preparation, making impedance based point-of-care diagnostics difficult to implement. By combining impedance measurements with flow focusing techniques, it was possible to enhance detection sensitivity without the requirement of a micron-sized orifice. Thus, a label-free biosensing system with tunable sensitivity was developed. Impedance spectroscopy was used to analyze samples, and this technique was extended to impedance tomography, with the ultimate goal of developing a system that can non-invasively monitor cellular environments and cell-cell interaction. The greatest challenge, by far, is improving sensitivity. Preliminary results have been encouraging and allow accurate localization of a particle. The long term goal of the research is to monitor physiological signals using impedance and biopotentials, in a smart sensor platform, with a special focus on wearable sensor technology.
Professor Mansoor Nasir received a B.Sc. in Electrical Engineering from University of Cincinnati and a Ph.D.in Bioengineering from the University of California -Berkeley. Thereafter, he pursued research interests, first as a postdoctoral associate, and then as a Research Scientist at the US Naval Research Laboratory in Washington DC. He is currently a faculty member in the Bioengineering Department at Lawrence Technological University. Professor Nasir has several publications in the areas of microfluidics, chemical and biological sensors and MEMS technology.