Current Issues in the Design and Analysis of Cluster Randomization Trials
Professor, Allan Donner, PhD, FRSC, Department of Epidemiology and Biostatistics and Robarts Clinical Trials, Schulich School of Medicine and Dentistry, Western University, London, Canada
Cluster randomization trials are those that randomize intact social units or clusters of individuals to different intervention groups.Such trials are particularly widespread in the evaluation of educational programs and innovations in the provision of health care. This talk will discuss current issues in the design and analysis of such trials that have proved controversial among practitioners. They include the choice of unit of inference, potential operational threats to trial validity, factors influencing the selection of a design, consideration of when non-randomized allocation might be preferred, and recent work focusing on ethical issues.