The Office of the Vice President of Research is pleased to host the John P. Oliver Nano@Wayne seminar on Tuesday, December 11, 2012 at 2:30 p.m. at the Welcome Center Auditorium. Dr. Juri Gelovani, chair and professor of the Department of Biomedical Engineering at Wayne State University, will be the presenter. Dr. Gelovani has recently founded a new field of imaging research - "Epigenetic Imaging." In addition, he is conducting multidisciplinary, collaborative research in bioengineering and nanoparticle-based imaging and therapy.
Dr. Gelovani's presentation, "Translation of Nano-theragnostic Agents into Clinic: Opportunities and Challenges," will focus on multifunctional nanoparticles (MFNPs) that have a significant potential for biomedical imaging, diagnostic and therapeutic or theragnostic agents. However, the larger size of MFNPs, as compared to small molecular drugs and diagnostic agents, creates several challenges on the path of their translation into the clinic. The major impediments are related to their size and physiochemical characteristics (i.e., which include hydrodynamic diameter, solubility, stablity, shape and flexibility, surface charge, composition and formulation) which determine their biodistribution, localization and retention at the target site, as well as with the clearance from the body after loco-regional or systemic administration. Several novel approaches to development and applications of theragnostic MFNPs will be discussed, including: tumor-targeted hollow gold nanoparticles (HGNPs) for imaging and delivery of siRNA and/or doxorubicin to tumors; detection of these HGNPs with opto-acoustic imaging and PET/CT, NIR-laser mediated release of therapeutic payloads from HGNPs and HGNP-medicated photothermal ablation of tumor tissues.
A reception will follow the presentation in the Welcome Center Lobby (3:30-4:00 p.m.)
Please note: Parking is available in Parking Structure No. 6, pull into the third gate, (visitors gate) and take a green receipt. Bring your receipt to the Nano@Wayne seminar registration desk in the Welcome Center for validation. Parking structure #6 is on Putnam between Cass and Woodward.