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March 20, 2018 | 2:30 p.m. - 3:30 p.m.
Category: Seminar
Location: Engineering, College of EDC Auditorium Room 1507 | Map
5050 Anthony Wayne
Detroit, MI 48202
Cost: Free
Audience: Academic Staff, Current Graduate Students, Current Undergraduate Students, Faculty, Staff

The Office of the Vice President for Research is pleased to host the Nano@Wayne seminar on Tuesday, March 20, 2018 at 2:30 p.m to 3:30 p.m. in the EDC Auditorium Room 1507 at the Engineering Building. The seminar is free and open to the public.

The Nano@Wayne Seminar Series presents, "Cells And Biomaterials As Micro- And Nanoscale Force Transduction Machines", with Sanjay Kumar, M.D., Ph.D., Professor and Associate Chair of Bioengineering at UC Berkeley, where he has been a faculty member since 2005. He is also Professor of Chemical and Biomolecular Engineering at UC Berkeley and a Faculty Scientist in the Biological Systems & Engineering Division of Lawrence Berkeley National Laboratory.  Dr. Kumar earned his B.S. in Chemical Engineering at the University of Minnesota (1996) and his M.D. and Ph.D. in Molecular Biophysics from Johns Hopkins University (2003).

Abstract:

Over the past two decades it has become clear that biophysical properties of the microenvironment can profoundly influence cellular mechanics and phenotype. This control is made possible by a series of micro- and nanoscale “machines” within the extracellular and intracellular spaces that convert mechanical and other biophysical inputs into biochemical signals.  His research group has developed and/or adapted a variety of single-cell technologies and micro/nanoengineered materials systems to probe, mimic, and exploit these relationships.  In this presentation, he will share recent efforts they have made to exploit next-generation matrix platforms whose material properties may be controlled in both time and space. First, he will discuss their use of a polymer hydrogel system that may be reversibly stiffened and softened through the use of oligonucleotide-based crosslinks, which they have used to identify a critical time window for mechanosensitive neural stem cell lineage commitment. Second, he will describe our combined use of single-cell photopatterning and femtosecond laser nanosurgery to probe the viscoelastic properties of actomyosin stress fibers with tightly standardized positions and lengths.

A short reception will immediately follow the seminar. 

For more information about this event, please contact Kayla Watson at 3135775600 or ft2868@wayne.edu.