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March 11, 2019 | 11:00 a.m. - 12:00 p.m.
Category: Seminar
Location: Integrative Biosciences Center IBio Conference Center | Map
6135 Woodward Ave.
Detroit , MI 48202
Cost: Free
Audience: Academic Staff, Alumni, Community, Current Graduate Students, Current Undergraduate Students, Faculty, Staff

The Campus Community is invited to a translational neurosciences research seminar

 Have No Fear: Crossing the Translational Bridge Between Mice and Men

hosted by

the Department of Psychiatry & Behavioral Neurosciences,

 and Translational Sciences and Clinical Research Innovation -  Office of the Dean of the School of Medicine and Office of the Vice President for Research

with guest speaker, Seth D. Norrholm, Ph.D., Emory University School of Medicine

March 11, 2019

11 a.m. to 12 noon

IBio Conference Center


The Wayne State University community is invited to attend a translational neurosciences research seminar with guest speaker, Seth D. Norrholm, Ph.D., associate professor, Department of Psychiatry and Behavioral Sciences, Emory University and Trauma Recovery Program - Atlanta VA Medical Center. 

The presentation will be held on March 11, 2019 at 12:00 noon in the first floor conference center of IBio, Located at 6135 Woodward. The seminar is free and open to the entire university community. 

Dr. Seth Norrholm will present, "Have No Fear: Crossing the Translational Bridge Between Mice and Men."

Dr. Seth Norrholm earned his B.A. degree in psychology at the University of Maryland at College Park, a M.A. degree in psychology/neuroscience at the University of Connecticut Health Center and a Ph.D. in psychology/neuroscience at Florida State University. 

Dr. Norrholm is a translational neuroscientist who studies trauma-, stressor- and anxiety-related disorders in combat and civilian populations. The primary objective of his work is to develop bench-to-bedside clinical research methods to inform therapeutic interventions for posttraumatic stress disorder and the disorders with which it is co-morbid. He has developed a conditioned fear extinction paradigm using fear-potentiated startle - a methodology that has the potential to be an effective outcome measure for PTSD treatment as well as an index of fear recovery.


Processing and regulation of fear is one of the key components of anxiety-, trauma-, and stressor-related disorders. Fear can involve both acute and potential threats that can manifest in different behaviors and result from activity within different neural nodes and networks.  Fear circuits have been studied extensively in animal models for several decades and in human neuroimaging research for almost twenty years. As such, the centrality of fear processing to fear and anxiety lends these disorders to be more tractable to investigation at the level of brain and behavior and provides several observable phenotypes that can be linked to clinical symptoms. For example, psychophysiological metrics of fear conditioning offer tools that can be used to shift diagnostic paradigms in psychiatry towards neurobiology—consistent with the NIH Research Domain Criteria (RDoC) approach.  In general, mammalian fear processing can be divided into fear learning (or acquisition), during which an association develops between previously neutral stimuli and aversive outcomes, and fear extinction, in which the latter associations are suppressed by a new form of learning. This seminar will review translational research in both fear acquisition and extinction and their relevance to human fear and anxiety and the treatment of these disorders, providing compelling examples from bench to bedside.

We hope you can join us for this interesting seminar!  

For more information about this event, please contact Julie O'Connor at 3135775600 or