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March 21, 2019 | 11:00 a.m. - 12:00 p.m.
Category: Seminar
Location: Integrative Biosciences Center 3rd floor Glass House | Map
6135 Woodward Ave.
Detroit , MI 48202
Cost: Free
Audience: Academic Staff, Alumni, Community, Current Graduate Students, Current Undergraduate Students, Faculty, Staff

The Campus Community is invited to a research seminar

Tackling Diabetes Via Novel Engineering and Photonics

hosted by

the Department of Chemical Engineering and Materials Science

and

The Office of the Vice President for Research

with guest speaker, Joe Fujiou Lo, Ph.D.

Associate Professor, Department of Mechanical Engineering

University of Michigan-Dearborn

March 21, 2019

11 a.m. to 12 noon

IBio Conference Center

 

The Wayne State University community is invited to attend a research  presentation with guest speaker, Joe Fujiou Lo, Ph.D., associate professor, Department of Mechanical Engineering, University of Michigan-Dearborn.

The presentation will be held on March 21, 2019 at 11:00 a.m. in the third floor Glass House of IBio, located at 6135 Woodward. The seminar is free and open to the entire university community. 

Dr. Lo will present, "Tackling Diabetes Via Novel Engineering and Photonics."

Dr. Lo earned his B.S. degree in Bioengineering at University of California and a Ph.D. in Biomeical Engineering at the University of Southern California. 

Abstract: 

Diabetes is a metabolic disease that exist across a continuum between genetic conditions and dietary/ environmental factors. Engineering offers a reductionist approach to unravel complex mechanisms of beta cell dysfunction in diabetes. My research tackles this complexity through two modalities: 1) revealing the basic pathogenesis at the pancreatic islet level, and 2) creating novel biophonic quantitation of diabetes’ impact on the tissue. In my islet pathogenesis work, I study the hypoxia and free fatty acid synergy in beta cell impairments, with potential epidemiological implications. Furthermore, the islet autoantigens generated during metabolic stress can lead to immunogenicity, and the visualization of this initial beta dysfunction suggests therapeutic strategies. While the endocrine-adipose communication implies dietary risks to diabetes, my research tracks the specific cytokine transports modulated in situ under these risk conditions. Lastly, fundamental fluid mechanics via novel 3D printing shows surface interactions with non-Newtonian flows that unveils potential shear-induced diabetes mechanisms. Conclusions from these shear-induced dysfunctions can demonstrate the vicious cycle of negative feedback in diabetes centered on microvasculature damage. In my biophotonics work, I developed a low-cost frequency domain fluorescence lifetime imaging (FLIM) modality to quantify the impact of diabetes on tissues and wounds. This technique was leveraged to build biophotonic models of diabetic ulcers and fibrosis, necessary steps for understanding and monitoring diseased tissues.

Exploring unconventional mechanisms and techniques provides a positive paradigm of the condition instead of viewing it through an inevitable disease progression. These efforts may prove potential interventions through pharmaceutical and/or lifestyle plus societal improvements.

We hope you can join us for this interesting seminar! 

For more information about this event, please contact Julie O'Connor at 3135775600 or julie.oconnor@wayne.edu.