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March 26, 2019 | 12:00 p.m. - 1:00 p.m.
Category: Seminar
Location: Integrative Biosciences Center IBio Conference Center | Map
6135 Woodward Ave.
Detroit , MI 48202
Cost: Free
Audience: Academic Staff, Alumni, Community, Current Graduate Students, Current Undergraduate Students, Faculty, Staff

The Campus Community is invited to a research seminar

Role of Necroptosis in Age-Associated Inflammation and Age-Related Disease

hosted by

the Departments of Physiology, Pathology and

Ophthalmology, Visual & Anatomical Sciences


The Office of the Vice President for Research

with guest speaker, Deepa Sathyaseelan, Ph.D.

Assistant Professor of Research, Reynold's Oklahoma Center for Aging

and Department of Biochemistry and Molecular Biology

University of Oklahoma Health Sciences Center

March 26, 2019

12 noon to 1 p.m.

IBio Seminar Room


The Wayne State University community is invited to attend a research  presentation with guest speaker, Deepa Sathyaseelan, Ph.D., assistant professor, Reynold's Oklahoma Center for Aging, University of Oklahoma Health Sciences Center.

The presentation will be held on March 26, 2019 at 12:00 noon in the first floor seminar room of IBio, located at 6135 Woodward. The seminar is free and open to the entire university community. 

Dr. Sathyaseelan will present, "Role of Necroptosis in Age-Associated Inflammation and Age-Related Diseases."

Dr. Sathyaseelan earned a Ph.D. in biochemistry at the University of Kerala, India.


Chronic, low-grade inflammation (inflammaging) is a hallmark of aging and is one of the ‘seven pillars of aging’. Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people because a variety of age-related diseases (e.g. type 2 diabetes, cardiovascular diseases, cancer, neurodegenerative diseases and frailty) share a strong inflammatory phenotype. Despite the link between inflammation, aging and age-associated diseases, two major gaps currently exist in our understanding of the role inflammation plays in aging: (1) the molecular mechanism(s)/pathway(s) responsible for the chronic, low-grade inflammation and (2) whether inflammaging is a causative factor in aging or occurs secondary to aging. My research focuses on the role of a newly discovered cell death pathway, necroptosis, which plays an important role in inflammation. Cell death from necroptosis generates DAMPs, which are strong activators of the inflammatory response. We recently discovered that necroptosis increases with age and is reduced by dietary restriction. In addition, necroptosis is dramatically increased in a mouse model of accelerated aging. My future studies will focus on whether inhibiting/blocking necroptosis by genetic and pharmacological approaches will reduce inflammaging, improve healthspan, and reduce the incidence of age-associated diseases such as type 2 diabetes.

We hope you can join us for this interesting seminar! 

For more information about this event, please contact Julie O'Connor at 3135775600 or