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April 3, 2019 | 1:00 p.m. - 2:00 p.m.
Category: Lecture
Location: Margherio Family Conference Center | Map
320 E. Canfield
Detroit, MI 48201
Cost: Free
Audience: Current Graduate Students, Faculty

Gerald I. Shulman, MD, PhD, George R. Cowgill Professor of Medicine and Cellular & Molecular Physiology, Yale University School of Medicine

“The New Biology of Type 2 Diabetes”

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a major factor in the pathogenesis of type 2 diabetes (T2D) and nonalcoholic steatohepatitis (NASH). This presentation will focus on the cellular mechanisms of liver and muscle insulin resistance in humans and the role of dysregulated intracellular lipid metabolism in its pathogenesis. Specifically this talk will review recent studies that have implicated increases in ectopic lipid content in causing insulin resistance in these organs as well as recent studies that have implicated diacylglycerol, as the molecular trigger for lipid-induced insulin resistance through its activation of PKC-epsilon in liver and PKC-theta in skeletal muscle leading to inhibition of insulin signaling and the identification of Thr1160 phosphorylation on the insulin receptor as a mediator of lipid-induced hepatic insulin resistance. This talk will also review recent studies that identify the link between white adipose tissue inflammation and increased rates of hepatic gluconeogenesis and fasting hyperglycemia in patients with type 2 diabetes due to increased rates of lipolysis leading to increased hepatic acetyl CoA content and allosteric activation of pyruvate carboxylase.

For more information about this event, please contact Suzanne Shaw at 577-5325 or sshaw@wayne.edu.