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April 18, 2019 | 11:00 a.m. - 12:00 p.m.
Category: Seminar
Location: Scott Hall #2268 | Map
540 E. Canfield
Detroit, MI 48201
Cost: Free
Audience: Current Graduate Students, Faculty

Leah Kottyan, PhD

Assistant Professor, Department of Pediatrics, Cincinnati Children's Hospital Medical Center

 “NFkB transcription factors operate across genetic risk loci: RELA in SLE, MS, and IBD”

 Abstract

Many immune associated diseases have a strong genetic etiology. The genetic variants that increase risk for these diseases are mostly non-coding: they do not affect amino acid usage in proteins. We hypothesize that these non-coding genetic risk variants affect disease risk through genotype-dependent regulation of gene expression. We found that NFkB transcription factors bind genetic risk variants more than would be expected by chance. We next found that the binding of the transcription factors was genotype-dependent. This talk will explore these findings and describe the experimental systems that we are using to demonstrate genotype-dependent transcription factor binding, DNA regulatory activity, and transcription.

 

For more information about this event, please contact Suzanne Shaw at 5775325 or sshaw@wayne.edu.