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June 24, 2019 | 11:30 a.m. - 12:30 p.m.
Category: Seminar
Location: Scott Hall #8366 | Map
540 E. Canfield
Detroit, MI 48201
Cost: Free
Audience: Academic Staff, Alumni, Community, Current Graduate Students, Current Undergraduate Students, Faculty, Staff

The Campus Community is invited to a research seminar  

"Impact of G-protein coupled receptor signaling in diet-induced atherogenesis" and “Emerging role of VEGFC in pathological retinal Neovascularization"

hosted by

Departments of Pathology, Physiology and


Ophthalmology, Visual and Anatomical Sciences

and

The Office of the Vice President for Research

with guest speaker, Nikhlesh Singh, DVM, PhD

Assistant Professor of Physiology

University of Tennessee Health Science Center

June 24, 2019

11:30 a.m. to 12:30 p.m.

8366 Scott Hall

The Wayne State University community is invited to attend a research  presentation with guest speaker, Nikhlesh Singh, DVM, PhD.

The presentation will be held on June 24, 2019 at 11:30 a.m. in 8366 Scott Hall. The seminar is free and open to the entire university community. 

Dr. Singh will present,“Impact of G-protein coupled receptor signaling in diet-induced atherogenesis" and “Emerging role of VEGFC in pathological retinal Neovascularization.”

Dr. Singh earned a DVM from GBPUA&T, Pantnagar India, a Master of Veterinary Science from the National Dairy Research Institute, ICAR, Karnal, India, and a Ph.D. from the National Dairy Research Institute ICAR, ICAR, Karnal, India.

Abstracts:

Title: “Impact of G-protein coupled receptor signaling in diet-induced atherogenesis.”

Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and adaptive immune responses and is an intrinsic cause of heart disease and stroke worldwide. Although many studies have suggested a strong link between coagulation pathways and atherogenesis, nothing is known regarding the role of thrombin or G-protein coupled receptor signaling in atherosclerosis. This talk will cover studies providing the first direct evidence for the possible role of thrombin-induced and Par1-mediated Gα12-Pyk2-Gab1-PKCθ-ATF2 signaling  on foam cell formation and atherosclerosis.

Title: “Emerging role of VEGFC in pathological retinal Neovascularization.”

Retinal neovascularization is the most common cause of moderate to severe vision loss in all age groups; i.e., retinopathy of prematurity (ROP) in children, diabetic retinopathy in adults and age-related macular degeneration in the elderly. Despite the use of anti VEGFA therapies, this complication continues to cause blindness, suggesting a role for additional molecules in retinal neovascularization. Besides VEGFA and VEGFB, hypoxia induced VEGFC expression robustly. This talk will present data showing the first direct effect of VEGFC on CREB-mediated DLL4-NOTCH1 activation, tip cell formation, sprouting and retinal neovascularization.

 

We hope you can join us for this interesting seminar!

For more information about this event, please contact Julie O'Connor at 313-577-5600 or julie.oconnor@wayne.edu.