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September 26, 2019 | 3:30 p.m. - 5:00 p.m.
Category: Lecture
Location: Physics Building #245
Cost: Free
Audience: Current Graduate Students, Current Undergraduate Students, Faculty

Abstract -- The fluidity of lipid membranes is essential to their biological function: cell membranes are required to be flexible, self-healing, and deformable. An additional consequence of membrane fluidity is that both lipids and proteins are highly mobile, which makes it possible for lipid-anchored proteins to travel long distances across the surface of cells. The significance of this lateral mobility for flow mechanosensing has not yet been determined. We study the mechanics of lateral membrane protein transport by flow in an in vitro model of the cell plasma membrane, lipid bilayers supported on glass. We prepare supported bilayers formed from individual GUVs inside microfluidic channels in order to study transport of membrane-anchored proteins. We observe and fit dynamic protein concentration gradients, which allow us to define protein mobility relative to a stationary lipid membrane. 

For more information about this event, please contact Jo Wadehra at 313 577 2740 or wadehra@wayne.edu.