Rho G Proteins in Islet Beta-Cell Function in Health and Diabetes

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Date: October 17, 2019
Time: 11:00 a.m. - 12:00 p.m.
Location: Scott Hall #3125 | Map
540 E. Canfield
Detroit, MI 48201
Category: Seminar

Anjan Kowluru, PhD

Distinguished Professor, Department of Pharmaceutical Sciences and of Internal Medicine, Wayne State University and Senior Research Career Scientist, John D. Dingell VA Medical Center

Glucose-stimulated insulin secretion (GSIS) involves interplay between metabolic and cationic events. Published evidence indicates novel regulatory roles for Rho subfamily of G-proteins (Rac1, Cdc42) in GSIS. Activation of these signaling proteins promotes cytoskeletal remodeling, transport and docking of insulin granules on the plasma membrane for exocytotic secretion of insulin. Furthermore, post-translational prenylation of these G-proteins is requisite for their targeting to appropriate cellular compartments for optimal regulation of effectors leading to GSIS. Our current understanding of roles of Rho G-proteins and their signaling networks in islet function in normal health, metabolic stress (glucolipotoxicity and ER stress) and diabetes will be discussed.
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Suzanne Shaw




Current Graduate Students, Current Undergraduate Students, Faculty

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