Rho G Proteins in Islet Beta-Cell Function in Health and Diabetes
This event is in the past.
Detroit, MI 48201
Anjan Kowluru, PhD
Distinguished Professor, Department of Pharmaceutical Sciences and of Internal Medicine, Wayne State University and Senior Research Career Scientist, John D. Dingell VA Medical Center
Glucose-stimulated insulin secretion (GSIS) involves interplay between metabolic and cationic events. Published evidence indicates novel regulatory roles for Rho subfamily of G-proteins (Rac1, Cdc42) in GSIS. Activation of these signaling proteins promotes cytoskeletal remodeling, transport and docking of insulin granules on the plasma membrane for exocytotic secretion of insulin. Furthermore, post-translational prenylation of these G-proteins is requisite for their targeting to appropriate cellular compartments for optimal regulation of effectors leading to GSIS. Our current understanding of roles of Rho G-proteins and their signaling networks in islet function in normal health, metabolic stress (glucolipotoxicity and ER stress) and diabetes will be discussed.