Inflammasome: Activation Mechanisms and Role in Inflammation

Thursday April 1, 2021 12:30- 1:30 PM

Presented by: Yuan He, Ph.D., assistant professor of Biochemistry, Microbiology and Immunology, Wayne State University

Yuan He, Ph.D., is the principal investigator of “Molecular Mechanism of NLRP3 Inflammasome Activation,” a five-year, $1.9 million grant from the National Institute of Allergy and Infectious Diseases. The project will investigate the molecular mechanism of a natural component of the human immune system that contributes to the pathogenesis of a variety of inflammatory diseases. The NLRP3 inflammasome is a critical component of the innate immune system that controls the secretion of pro-inflammatory cytokines interleukin ( IL)-1β and IL-18 in response to infection and tissue damage. Aberrant activation of the NLRP3 inflammasome, Dr. He said, contributes to the pathogenesis of several inflammatory disorders, including Cryopyrin-associated autoinflammatory syndrome, gout, diabetes, and Alzheimer’s disease. “The goal of this project is to better understand how the NLRP3 inflammasome is activated,” he said. “Understanding the mechanism of NLRP3 inflammasome activation might guide the development of novel therapeutic strategies for treating NLRP3 inflammasome-driven inflammatory diseases.”

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Meeting ID: 977 8751 3998

Passcode: 754272

For Additional Information contact marshamoore@wayne.edu or visit us at www.cures.wayne.edu

The Center for Urban Responses to Environmental Stressors is funded by NIEHS #P30ES020957