“Pancreatic Beta Cell Autophagy in the Pathogenesis of Type 1 Diabetes”

Warning Icon This event is in the past.

Date: May 6, 2021
Time: 11:00 a.m. - 12:00 p.m.
Location: Virtual event
Category: Seminar

Amelia K. Linnemann, PhD

Assistant Professor of Pediatrics, Indiana University School of Medicine.  Dr. Linnemann is also an alumnus of Wayne State University’s Molecular Genetics and Genomics PhD program.  

 “Pancreatic Beta Cell Autophagy in the Pathogenesis of Type 1 Diabetes”

Abstract

Pancreatic beta cells are subjected to exogenous damaging factors such as proinflammatory cytokines or excess glucose that can cause accumulation of reactive oxygen species (ROS) during the pathogenesis of type 1 diabetes. Accumulation of ROS can disrupt cellular homeostasis, leading to oxidative damage and apoptosis. However, the activation of endogenous adaptive response mechanisms such as the antioxidant response and autophagy can counter the damaging effects of ROS accumulation and promote the restoration of cellular homeostasis. In this presentation, Dr. Linnemann will discuss how defects in this adaptive response contribute to beta cell dysfunction and apoptosis.

Contact

Suzanne Shaw
577-5325
sshaw@wayne.edu

Cost

Free
May 2021
SU M TU W TH F SA
2526272829301
2345678
9101112131415
16171819202122
23242526272829
303112345