“Examination of in vivo neuronal mitophagy”

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Date: November 4, 2021
Time: 11:00 a.m. - 12:00 p.m.
Location: Please contact Suzanne Shaw at sshaw@wayne.edu for seminar Zoom link
Category: Seminar

Ryan Insolera, PhD

Assistant Professor, Department of Ophthalmology, Visual and Anatomical Sciences, Wayne State University 

“Examination of in vivo neuronal mitophagy”

Abstract

Neurons are critically reliant on a healthy population of mitochondria to fuel their persistent high energy demands. Active maintenance is required throughout life to maintain healthy mitochondria in neurons, which includes the efficient degradation of old and/or damaged mitochondria. Mutations in genes implicated in mitophagy, which is the major cellular mechanism of mitochondrial degradation, are often causal to neurodegenerative diseases, yet, almost nothing is known about mitophagy in neurons in vivo. Using the model organism Drosophila melanogaster, we have made novel discoveries in the molecular mechanisms of neuronal mitophagy in fly neurons. In my seminar, I will discuss our work demonstrating the importance of the inter-organelle lipid transporters in the Vps13-gene family in neuronal mitophagy, as well as the characterization of the Drosophila homolog of mammalian optineurin as the putative mitophagy receptor in fly neurons.

Contact

Suzanne Shaw
313-577-5325
sshaw@wayne.edu

Cost

Free
November 2021
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