“From the Livers to Blood and back – the Reciprocal Regulation between Lipids and Blood Clot Lysis”

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Date: October 5, 2022
Time: 11:00 a.m. - 12:00 p.m.
Location: Scott Hall # 3125 | Map
Category: Seminar

Ze Zheng, MBBS, PhD
Assistant Professor of Medicine at the Medical College of Wisconsin, and Associate Investigator at the Versiti Blood Research Institute
“From the Livers to Blood and back – the Reciprocal Regulation between Lipids and Blood Clot Lysis”

Abstract

After graduating from the Molecular Genetics and Genomics PhD program at Wayne State University, Dr. Ze Zheng studies the reciprocal regulation between lipid/lipoprotein metabolism and blood clot lysis. Her previous study revealed a novel cellular source of circulating tissue-type plasminogen activator (tPA), the key blood clot lysis serine protease, derived from hepatocytes. She further investigated the mechanism of how hepatocytes sense metabolic stresses and imbalance the production of tPA and PAI-1, a serpin inhibitor, influencing the degree of impaired fibrinolysis in obesity. Her recent studies discovered a novel intracellular function of tPA that limits the assembly of atherogenic apoB-containing lipoprotein particles in the hepatocytes.

 

Zoom Link: https://wayne-edu.zoom.us/j/91228061215?pwd=SzdEeU5icWtsMURqdUR5VGlKOW9JZz09

Contact

Suzanne Shaw
577-5325
sshaw@wayne.edu

Cost

Free
October 2022
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