Eicosanoids in the resolution of murine Lyme arthritis
This event is in the past.
Detroit, MI 48202
Charles R. Brown, Ph.D.
Professor, Veterinary Pathobiology
Department of Molecular Microbiology and Immunology
University of Missouri School of Medicine, Columbia, MO
Lyme arthritis is a common late-stage manifestation of infection and without prompt treatment with antibiotics can persist for months or years. Inhibition of either COX or LOX metabolic pathways has little effect on the development of Lyme arthritis in mice, but does inhibit arthritis resolution. Mechanisms involving PGE2 and LTB4 play important, but different, roles in mediating clearance of apoptotic neutrophils from the inflamed joint and 12/15-LO products are also likely playing a role. These mechanisms and more will be discussed.
Krishna Rao Maddipati