CBI: Peter Caravan, Mass General

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Date: April 28, 2023
Time: 2:30 p.m. to 3:30 p.m.
Category: Seminar
CBI: Peter Caravan, Director of the Institute for Innovation in Imaging at Massachusetts General Hospital and Professor of Radiology at Harvard Medical School.
Talk topic: Metals in Medicine:  Developing new imaging probes for PET and MRI (Hosts: Pflum/Chow)
Abstract:  Most therapeutic drugs, with some notable exceptions, are organic compounds that do not contain a metal ion.  On the other hand diagnostic drugs, or imaging agents, often contain a metal ion which enables detection with the particular imaging modality.  For MRI, complexes of Gd(III) and Mn(II) have been used clinically as well as iron oxide nanoparticles.  For computed tomography, high atomic number elements like barium are used for X-ray attenuation.  For nuclear imaging techniques like positron emission tomography (PET) and single photon emission computed tomography (SPECT) there are products based on Ga-68, Cu-64, Tc-99m, and Tl-201 among other isotopes.  In this lecture, I will describe  two imaging probes that were invented in our lab and that are now undergoing human clinical trials. I will describe the bench to bedside translation and discuss the medical need that led to the invention of these probes, the chemistry to identify and optimize the probes, their chemical and biological validations, and examples from the clinical trials. 64Cu-FBP8 is a probe that specifically targets the protein fibrin which we are using to detect thrombosis (blood clots) and extravascular coagulation anywhere in the body using PET imaging.  RVP-001 is a Mn(II) based probe used in MRI to detect cancer and inflammatory lesions.

April 2023