Yong Tae Kwon, Ph.D., professor of Biomedical Sciences at Seoul National University and chief executive officer at AUTOTAC Bio Inc., will present “The AUTOTAC chemical platform: Preclinical Showcases of Autophagy-Mediated Targeted Degradation in Drug Discovery."

His visit is a special seminar hosted by the Wayne State University Department of Pathology and the Barbara Ann Karmanos Cancer Institute. 

Dr. Kwon developed a targeted degradation platform, termed AUTOTAC (Autophagy Targeting Chimera) that enables autophagic degradation of a variety of proteins and other non-proteinaceous materials. By employing a bi-functional chimera that brings a target to p62 for lysosomal degradation, this technology was successfully used to degrade various targets ranging from neurodegeneration-associated pathogenic aggregates. In 2018, he founded AUTOTAC Bio Inc. to develop drugs that induce the autophagic degradation of disease-associated proteins and other cellular materials, amongst which the first drug received IND approval from Korea FDA to treat Alzheimer’s disease (AD), Progressive supranuclear palsy (PSP), and amytrophic lateral sclerosis (ALS). 

Zoom info:

https://wayne-edu.zoom.us/j/96489466613?pwd=T1VoSlR1L2hMTXVESzllMEFwRFgyUT09

Meeting ID: 964 8946 6613

Password: 469664