Speaker

Dr. Jie Fan, PhD, University of Michigan-Dearborn

Abstract

The human body, often regarded as the most intricate machine on Earth, possesses a remarkable left-right asymmetry. Within this complex system, trillions of cells of diverse types function as the fundamental units supporting life. Recent discoveries have unveiled an inherent property of cells known as cell handedness or chirality, wherein cells exhibit a distinct left-right asymmetry akin to the human body. This presentation will focus on introducing our recent studies on cell chirality, specifically in regard to 1) the influence of cell chirality and its regulation on the permeability of the endothelial barrier; 2) the role of endothelial cell chirality during metastasis; 3) the left-right asymmetrical positioning of cell organelles in single cells. The exploration of cell chirality will help us to understand the chiral structure of cells and its potential implications for human health.