Wayne State University School of Medicine

Dept. of Psychiatry and Behavioral Neurosciences

Chairman's Grand Rounds

Date: Wednesday, March 20, 2024

Time: 1-2pm

Venue: Margherio Family Conference Center - 1st Floor

SPEAKER: 

Jeffrey A. Stanley, Ph.D.

Professor

Dept. of Psychiatry and Behavioral Neurosciences

Wayne State University School of Medicine

No Commercial Relationship 

TOPIC: 

"Exploiting MR Relaxation Phenomena to Advance the Understanding of White Matter Microstructure: Its Application to Development/Aging and Psychiatric Disorders"

Objectives:

1.  Describe why the corpus callosum is a perfect system for analyzing the microstructure of white matter

from the perspective of axon diameter distribution and packing density of fibres.

2.  Describe a conceptual framework of myelination during development and its impact on axon size and packing density.

3.  Describe the methodology of myelin water imaging and the biological significance of the outcome measurements to the white matter microstructure.

4.  Provide evidence of age-related differences in the microstructure of the corpus callosum and other white matter tracts, as well as altered white matter microstructure in disorders such as schizophrenia.