Trond M. Michelsen, MD PhD

Senior Consultant, Department of Obstetrics, Oslo University Hospital and Professor, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Norway

“Placental glucose metabolism in vivo – a human model”

Abstract

Dr. Michelsen’s lab has developed an in vivo sampling method performed during cesarean delivery. The method involves blood sampling from maternal artery and uterine vein and the umbilical artery and vein while the placental circulation is still running. These analyses are combined with ultrasound Doppler measurements to determine flux of glucose and other substances between the mother, placenta and fetus.
Alterations in placental glucose metabolism have been associated with pregnancy complications such as gestational diabetes and intrauterine growth restriction. Understanding the intricate mechanisms of placental glucose metabolism is essential for improving maternal and fetal outcomes in pregnancy. The findings from Dr. Michelsen’s lab support that the placenta plays a crucial role in regulating glucose metabolism to support the growth and development of the fetus.