According to the inflammation hypothesis of diseases, persistent (i.e. chronic) inflammation is the driver of all chronic diseases such as diabetes, arthritis, cardiovascular diseasees, muscular dystrophy, etc., including cancer. Chronic inflammation is traditionally viewed as an extension of acute inflammation that is poorly resolved. However, biochemical evidence suggests that chronic inflammation is a result of perturbation in a homeostatic physiological process called unalamation and NOT inflammation in the traditonal sense. This new understanding has profound implications for the treatment of chronic diseases and cancer.