Barber Center: Molecular mechanisms of PLIN binding
This event is in the past.
3:30 p.m. to 5 p.m.
All are welcome to attend a presentation by Dr. Amit Kumar as he reviews recent discoveries on the molecular mechanisms of PLIN3/4 binding to lipid droplets, as recently published in the articles cited below.
This presentation will occur in person in the third-floor conference room of the Physics Research Building.
Phosphatidylethanolamine binds to human perilipins via a hydrophobic cleft in their 4-helix bundle domain for lipid droplet targeting.
Stribny J, Schneiter R.
J Biol Chem. 2026 Aug;302(8):113268. doi: 10.1016/j.jbc.2026.113268. Epub 2026 Jun 19. PMID: 42320629; https://pubmed.ncbi.nlm.nih.gov/42320629/
Comparison of the 4-helix bundle domains of perilipin 3 and perilipin 4 identifies features that contribute to lipid droplet binding.
Cyril Moulin, Bayane Sabbagh, Amel Bahloul, Nicolas Fuggetta, Romain Gautier, Alenka Čopič,
bioRxiv 2026.08.15.745046; doi: https://doi.org/10.64898/2026.08.15.745046