Please join Wayne State University's Center for Urban Responses to Environmental Stressors (CURES) for their upcoming seminar on April 18, 2024 at 12:30 to 1:30 p.m. ET. The seminar will be offered virtually and is free to attend; registration is required. The Zoom link will be emailed to all registrants prior to April 18.

The guest speaker will be Dr. Xinxin Ding, professor and head of the Department of Pharmacology and Toxicology, College of Pharmacy, University of Arizona. Dr. Ding will present, "Metabolic Mechanisms of Chemical Toxicity in the Lung."

Abstract:

The lung is the prime, and often preferential, target for the adverse effects of various airborne toxicants, including those found in dusts, fire smoke, and environmental tobacco smoke. The mechanisms for such toxicity, ranging from acute tissue injury and inflammation to chronic diseases such as lung fibrosis, obstructive pulmonary disease, and cancer, are not well understood. For compounds that require bioactivation to cause toxicity, a critical knowledge gap exists regarding the ability of reactive metabolites formed in the liver to be distributed to secondary sites such as the lung to cause toxicity. Furthermore, exposure related effects on tissue repair are unclear, which may also affect the toxicity outcome. This talk will discuss recent progress in our efforts to address these mechanistic questions, which are important for assessing the risks of lung toxicity in exposed communities.

Biography:

Dr. Xinxin Ding received his B.S. degree in Biology from Nanjing University, Nanjing, China, in 1982, and Ph.D. degree in Biological Chemistry, from the University of Michigan in Ann Arbor, MI, in 1988. He is currently Professor and Head of the Department of Pharmacology and Toxicology, College of Pharmacy, and a member of the Bio5 Institute, the Cancer Center, and the Southwest Environmental Health Sciences Center, at the University of Arizona, Tucson, AZ. He is also Director of the NIEHS Superfund Research Center at the University of Arizona. Prof. Ding has broad research interest in various areas of Pharmacology and Toxicology, including drug metabolism, chemical carcinogenesis, and mechanistic toxicology, and their applications in drug development, disease prevention, and precision medicine. Prof. Ding is an author or co-author of more than 180 original research papers. He serves as Editor-in-Chief of the journal Drug Metabolism and Disposition and Secretary/Treasurer of the American Society for Pharmacology and Experimental Therapeutics.