Cholesterol and cancer: New mechanisms and therapy
This event is in the past.
4 p.m. to 5 p.m.
Reprogramming of lipid metabolism is an important hall mark of cancer cells that is linked to therapy resistance. Through spatiotemporally resolved quantitative lipid imaging, we have discovered that site-specifically enriched cholesterol in cancer cells orchestrates complex cell-autonomous oncogenic signaling networks that constitutively drive cell stemness and resistance to cell death. Proximity labeling analysis identified a number of kinases, phosphatases, and scaffolding proteins that are directly and specifically controlled by cholesterol. Small molecule inhibitors specifically targeting cholesterol-protein interaction serve as potent and specific cancer type-specific therapeutic agents with novel pharmacological properties, including suppression of cancer cell stemness and drug resistance.
Contact
Chisom Joshua Onu
3137278855
chisomjoshua@wayne.edu