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Integrative Biosciences Center (IBIO)

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June 14, 2017 | 11:00 a.m. - 12:00 p.m.
Category: Seminar
Location: Integrative Biosciences Center IBio Conference Center | Map
6135 Woodward Ave.
Detroit , MI 48202
Cost: Free
Audience: Academic Staff, Community, Current Graduate Students, Current Undergraduate Students, Faculty, Staff

IBio Faculty Candidate Seminar

June 14, 2017 - 11 a.m. to 12 noon

IBio Conference Center

Benjamin Gantner, Ph.D. - Senior Research Specialist, University of Illinois Chicago

"Intravital Imaging Reveals Novel Inflammatory Programming by Macrophages"

Please join us on June 14, 2017 for an IBio Faculty Candidate Seminar with Dr. Benjamin Gantner, senior research specialist in the Department of Microbiology and Immunology at the University of Illinois Chicago.

Dr. Gantner received his Ph.D. in immunology from the University of Washington Seattle, where he studied the interaction of Dectin-1 and Toll-like Receptor 2: Recognition of pathogens through both phagocytic and inflammatory receptors shapes the phagocyte inflammatory response. He received his B.A. in anthropology from the University of Illinois Urbana-Champaign. Dr. Gantner's current research focuses on the innate immune inflammatory signal transduction in response to bacterial pathogens, and virulence determinants targeting host immune response in bacterial pathogens.

Abstract

Inflammation resulting from infection promotes antimicrobial responses and drives the development of sterilizing immunity. However, the tissue injury that accompanies inflammation can compromise organ function and cause disorders such as acute respiratory distress syndrome (ARDS). ARDS is a complication of sepsis and pneumonia with significantly higher mortality among racial minorities in the United States. The mechanisms underpinning this are poorly understood and clinical interventions remain limited because anti-inflammatory treatments compromise the control of underlying infections. We identified a critical role for neuronal nitric oxide synthase (NOS1 or nNOS) in promoting the NF-κB pathway in macrophages and demonstrated that it is required for the lung vascular injury seen in model ARDS. Despite this, NOS1 is not required for robust recruitment of neutrophils to the lung, an observation made with a cutting edge intravital imaging technique for live, ventilated lungs. Our studies reveal a novel mode of innate inflammatory programming and provide a framework for investigating the balance between effective antimicrobial responses and inflammatory injury in ARDS.

For more information about this event, please contact Julie O'Connor at 3135775600 or julie.oconnor@wayne.edu.