Computational Modeling and Simulation of Ligand-Gated Ion Channels

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Date: January 26, 2021
Time: 3:30 p.m. - 4:30 p.m.
Location: Zoom
Category: Seminar

Presenter: Dr. Rezvan Shahoei from the University of Illinois at Urbana-Chapaign

Abstract: Pentameric ligand-gated ion channels, from bacteria to the brain, convert chemical signals into electric signals. In this talk, I will present the results from two projects in which molecular dynamics (MD) simulations and MD-based methods are utilized to study two members of this protein superfamily and their interactions with small molecules. The first project focuses on menthol binding to the most abundant nicotinic acetylcholine receptor in the brain. In the second project, MD simulations are used to determine the functional states of experimentally-derived models of the human α1 glycine receptor. 

Contact

Joseph Sklenar
440-225-9932
jnsklenar@wayne.edu

Cost

Free
January 2021
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