Imad Shureiqi, MD

Professor

Department of Internal Medicine,

University of Michigan, Ann Arbor

Abstract

15-Lipoxygenase-1 (ALOX15) is a critical enzyme for producing various inflammation-regulatory lipid signaling mediators, including 13-S-hydroxyoctadecadienoic acid (13-S-HODE) from linoleic acid, lipoxins from arachidonic acid, and resolvins from eicosapentaenoic and docosahexaenoic acids. Given ALOX15’s crucial regulatory roles of terminal cell differentiation and inflammation, its expression is inducible and highly regulated in normal human cells. ALOX15 expression is transcriptionally silenced in various major human cancers. ALOX15 re-expression suppresses colorectal carcinogenesis by restoring oxidative metabolism of linoleic acid and other polyunsaturated fatty acids.