Wayne State University

 
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Physics & Astronomy

October 26, 2017 | 3:45 p.m. - 5:00 p.m.
Category: Seminar
Location: Physics & Astronomy Department - Liberal Arts and Sciences #245 | Map
666 W. Hancock
Detroit, MI 48201
Cost: Free
Audience: Academic Staff, Alumni, Community, Current Graduate Students, Current Undergraduate Students, Faculty

Nanoscale membrane curvature revealed by polarized localization microscopy

Christopher Kelly, Department of Physics and Astronomy, Wayne State University

Many essential biological processes depend on the interaction of lipids, proteins, and carbohydrates at length scales that are unresolvable by conventional optical microscopes. We have combined super-resolution microscopy methods to create polarized localization microscopy (PLM). With PLM, we have measured membrane curvature as small as 20 nm radii, measured curvature-induced molecular sorting, and a local change in the local membrane viscosity. Further, we have discovered that cholera toxin subunit B self-assembles to form nanoscale membrane buds in quasi-one component bilayers to facilitate its immobilization and internalization into cells. We will discuss the physics of PLM and the mechanisms by which cholera toxin bends membranes.

For more information about this event, please contact Zhi-Feng Huang at (313) 577 2791 or huang@wayne.edu.