Wayne State University

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Physics & Astronomy

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November 9, 2017 | 3:45 p.m. - 5:00 p.m.
Category: Seminar
Location: Physics & Astronomy Department - Liberal Arts and Sciences #245 | Map
666 W. Hancock
Detroit, MI 48201
Cost: Free
Audience: Academic Staff, Alumni, Community, Current Graduate Students, Current Undergraduate Students, Faculty

High-speed single molecule tracking of proteins in E. coli

Ken Ritchie, Department of Physics and Astronomy, Purdue University

All living cells are encapsulated by an outer envelope, which contains a fluid phospholipid-based membrane that structurally delineates the inside of the cell from its environment. Embedded within this membrane is the machinery (proteins) required for the cell to sense and interact with its environment. As such, one expects that there are mechanisms in place to control the location and mobility of the membrane proteins in the fluid membrane in order to perform complex and critical tasks. In this talk, I will present our group’s recent single molecule mobility studies into the (dynamic) organization of the cellular membranes of E. coli bacteria performed at acquisition rates up to 1 kHz. Examples will include the structure of the polar region of the inner membrane as seen by the serine chemoreceptor Tsr and investigations into interactions of the iron transporter FepA in the E. coli outer membrane with the inner membrane protein TonB.

For more information about this event, please contact Zhi-Feng Huang at (313) 577 2791 or huang@wayne.edu.