Detroit , MI 48202
The Center for Urban Responses to Environmental Stressors (CURES) and Integrative Biosciences presents their Thursday afternoon seminar series on March 23, 2017 from 12:30 to 1:30 p.m. at the IBio Building in Seminar Room 1D, located at 6135 Woodward Ave. The seminar is free and open to the entire university community.
The guest speaker will be Jason R. Cannon, Ph.D., associate professor of toxicology in the School of Health Sciences at Purdue University. Dr. Cannon will present, "Environmental and mechanistic investigations of early-stage Parkinson’s disease."
Dr. Cannon received his B.S. in physiology from Michigan State University, his Ph.D. in toxicology from the University of Michigan, and was a postdoctoral fellow at the Pittsburgh Institute of Neurodegenerative Diseases at the University of Pittsburgh. He teaches courses in analytical, pathological, and biochemical toxicology and performs mechanistic research on the environmental bases of Parkinson’s disease. His research group is particularly interested in the following topics related to Parkinson’s disease: 1) Neurotoxicity of heterocyclic amines, which are compounds formed during high temperature cooking; 2) How environmental insults may disrupt autophagy and lead to neuronal cell death; 3) How specific genetic factors can increase sensitivity to environmental insults. The lab utilizes neurobehavioral, biochemical, and histological techniques to address these topics.
In this seminar, Dr. Cannon will address what he believes to be two important gaps in Parkinson’s disease (PD) literature: 1) the identification of etiological factors that represent commonly encountered exposures, and 2) elucidation of pathogenic mechanisms important in the earliest stages of the disease. PD is characterized by debilitating cardinal motor symptoms and often, the presence of many difficult to treat non-motor symptoms. He will detail their efforts to explore dietary factors that represent common exposures and could potentially impact PD etiology. His group has become especially interested in the neurotoxicity of heterocyclic amines, compounds which can be formed in the preparation of many foods. Additionally, their mechanistic studies are primarily focused on the pathogenic features of early-stage PD, where they aim to identify biomarkers and new therapeutic targets. Here, their work focuses on both dopaminergic dysfunction responsible for motor symptomology and also other systems that are linked to many nonmotor symptoms. In this area, they have identified a specific biochemical pathway important in autophagy that may be affected in early-stage PD. To accomplish their goals, Cannon and his team are using cellular, nematode, amphibian and rodent models. In discussing their findings, Cannon aims to address the advantages and limitations of each research model.
We hope you can join us for this interesting seminar!