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January 11, 2018 | 12:30 p.m. - 1:30 p.m.
Category: Seminar
Location: Integrative Biosciences Center 1D
Cost: Free
Audience: Academic Staff, Alumni, Community, Current Graduate Students, Current Undergraduate Students, Faculty, Prospective Students, Staff

The Center for Urban Responses to Environmental Stressors (CURES) presents their Thursday afternoon seminar series on Thursday, January 11, 2018 from 12:30 to 1:30 p.m. at the IBio Building in Seminar Room 1D, located at 6135 Woodward Ave.  The seminar is free and open to the entire university community.

The guest speaker will be Todd Lydic, Ph.D., Research Specialist and Director of the Collaborative Mass Spectrometry Core Facility, Molecular Metabolism and Disease Program, Michigan State University.  Dr. Lydic will present "Bridging Biological and Chemical Sciences to Identify Metabolic Signatures of Disease and Environmental Exposures".

Dr. Lydic received a Bachelors of Arts in Sociology, Bachelors of Science in Biochemistry and a Doctoral degree in Physiology from Michigan State University.

ABSTRACT

Recently there has been an increasing recognition that perturbations of metabolic pathways related to lipid biosynthesis, turnover, and signaling can play key roles in the onset and progression of many human diseases.  However, analytical strategies to facilitate characterization of lipids and lipid metabolites (i.e., "lipidomics") in biological systems are less established than "omics" technologies employed for proteins, nucelic acids, or polar small molecules, and current lipidomics methodologies often fall short of delivering a truly comprehensive picture of global lipid metabolism.  Therefore, we developed an enhanced lipidomics approach to enable the simultaneous analysis of structurally diverse lipid sub-classes based on the extraction of lipids from cells or tissues using a simple monophasic extraction strategy that promotes recovery of a broader range of lipid classes than traditional methods, in conjucntion with novel sample derivatization techniques.  Coupling this sample preparation approach with lipid analysis by direct infusion high resolution/accurate mass spectrometry has allowed us to overcome many limitations of commonly employed lipidomics platforms, and greatly expand coverage of the lipidome while reducing the required analysis time.  The application of this lipidomics approach to models of colon cancer and dioxin-induced hepatic steatosis demonstrate the ability of lipidomics to elucidate unique metabolic signatures of disease and environmental exposures, while providing novel insights into pathophysiological processes at the molecular level.  The future potential to conduct "multi-omics" analyses to bridge disparate analytical realms and provide truly global metabolic snapshots of disease or environmental exposures will also be discussed.

For more information about this event, please contact Christina Cowen at 313-577-6590 or mzchris@wayne.edu.