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Research and Discovery | Research Events

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December 12, 2019 | 11:00 a.m. - 12:00 p.m.
Category: Seminar
Location: Scott Hall #3125 | Map
540 E. Canfield
Detroit, MI 48201
Cost: Free
Audience: Current Graduate Students, Current Undergraduate Students, Faculty

A. Phillip West, PhD

Assistant Professor of Microbial Pathogenesis and Immunology, College of Medicine, Texas A&M University

“Mitochondrial control of innate immunity and inflammation: implications for mitochondrial disease and aging”

ABSTRACT

It is increasingly well appreciated that mitochondria are key modulators of mammalian immunity. For example, my lab and others have shown that mitochondrial DNA (mtDNA) stress/instability is a potent trigger of pattern recognition receptors of the innate immune system and can drive both pro-inflammatory and type I interferon responses during infection and disease. My seminar will focus on how mtDNA instability engages the cGAS-STING DNA sensing axis, and I will present new data linking this signaling pathway to pathological metabolic and immune rewiring in a model of Polymerase gamma (POLG)-related mitochondrial disease and premature aging.

 

For more information about this event, please contact Suzanne Shaw at 313-577-5325 or sshaw@wayne.edu.