Mitochondrial Transplantation: Applications and Potential
This event is in the past.
Detroit, MI 48201
James D. McCully, PhD
Associate Professor of Surgery, Harvard Medical School and Staff Scientist, Department of Cardiac Surgery, Boston Children’s Hospital
“Mitochondrial Transplantation: Applications and Potential”
Mitochondria play a key role in the modulation of ischemia- reperfusion injury (IRI). We and others have shown that IRI has detrimental effects on mitochondrial function and cellular energetics, which in turn negatively impacts post-ischemic myocardial contractile function and cellular viability. Premised on these findings, we have pioneered a novel therapy, mitochondrial transplantation, consisting of replacing native mitochondria damaged by IRI with viable, structurally intact, respiration-competent mitochondria isolated from non-ischemic tissues obtained from the patient’s own body. This presentation will expand upon the safety and efficacy of mitochondrial transplantation in vitro, in vivo as well as in human pediatric cardiac patients.