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May 21, 2019 | 12:00 p.m. - 1:00 p.m.
Category: Seminar
Location: Scott Hall Margherio Family Conference Ctr | Map
540 E. Canfield
Detroit, MI 48201
Cost: Free
Audience: Academic Staff, Alumni, Community, Current Graduate Students, Current Undergraduate Students, Faculty, Staff

The Campus Community is invited to a research seminar  

Molecular control of myelin formation

hosted by

the Department of Neurology

and

The Office of the Vice President for Research

with guest speaker, Benny "Benayahu" Elbaz, Ph.D.

Research Assistant Professor, Center for Peripheral Neuropathy

University of Chicago School of Medicine

May 21, 2019

12 p.m. to 1 p.m.

Margherio Family Conference Center

Scott Hall

The Wayne State University community is invited to attend a research  presentation with guest speaker, Benayahu "Benny" Elbaz, Ph.D., research assistant professor, Center for Peripheral Neuropathy, University of Chicago School of Medicine.

The presentation will be held on May 21, 2019 at 12:00 noon in the Margherio Family Conference Center located at Scott Hall. The seminar is free and open to the entire university community. 

Dr. Elbaz will present, "Molecular control of myelin formation."

Dr. Elbaz earned his B.S. degree in biology at Bar Ilan University and a Ph.D. in biochemistry and molecular biology at the Hebrew University of Jerusalem. 

Abstract: 

Myelin is a highly ordered multilayer lipid membrane structure that ensheaths and insulates axons, allowing for the efficient propagation of action potentials along axons. Myelination is a developmental process that in rodents begins at birth and is largely completed by early adulthood. Myelin is formed by myelinating cells; oligodendrocytes in the CNS and Schwann cells in the PNS.  These cells play a role in a variety of neurological disorders to a far greater extent than formerly realized: this includes being previously unsuspected disease targets, as well as critical participants in protection and repair. My research is focused on understanding the tight molecular control of lineage progression, differentiation and myelin gene expression in oligodendrocytes in the CNS and in Schwann cells in the PNS. In the CNS my research has been focused on the transcription factor ZFP24. My studies suggest that dephosphorylation of ZFP24 mediates its binding to the enhancer regions of genes important for oligodendrocyte differentiation and myelination. In the PNS, my studies have demonstrated that the Wnt signaling modifying protein Adenomatous Polyposis Coli (APC) is crucial for radial axonal sorting and PNS myelination. Complete understanding of the molecular cues that control myelin formation is crucial in our attempts to intervene and enhance remyelination of the CNS and the PNS following demyelinating injuries, such as multiple sclerosis in the CNS and peripheral neuropathy in the PNS.

We hope you can join us for this interesting seminar!  

For more information about this event, please contact Julie O'Connor at 3135775600 or julie.oconnor@wayne.edu.